Syringe filters are used in analytical chemistry applications to remove particulate contamination prior to analysis. Filtering a sample prior to sample injection into analytical instrumentation will help protect sensitive parts of the instrument from particulate build-up and reduce system downtime. Sample filtration using syringe filters containing 0.45 μm (HPLC) or 0.2 μm (UHPLC) pore size membranes will also extend the life of chromatography columns by preventing particulate from blocking the flow path between the column packing. Pall’s Acrodisc One PSF Syringe Filters with wwPTFE membranes have been designed to protect analytical instrumentation and improve the reliability of results. wwPTFE membrane devices are chemically compatible with a wide variety of common solvents and are suitable for use in both aqueous and organic applications. These syringe filters are constructed with solvent compatible polypropylene material. The polypropylene plastic provides the syringe filter with exceptional strength, it is the highest grade of plastic with minimal additives and passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> plastics testing. Both the wwPTFE membrane and polypropylene housing are extremely low in levels of potential extractables that can lead to chromatographic interference. The devices are low in protein and API binding which make them ideal for drug studies, such as dissolution testing. The GxF/wwPTFE membrane configuration features a a GxF multi-layer glass fiber prefilter, providing two to four times the throughput of standard prefilter devices. The multi-layer prefilter captures particulate rated from > 40 to 1 μm.